Issaquena County holds a remarkable distinction: it is the least populated county in Mississippi, with fewer than 1,400 residents. Located in the western Delta along the Mississippi River, the county has no incorporated towns — Mayersville, the county seat, is an unincorporated community. The landscape is Delta at its most elemental — flat, fertile farmland bordered by the Mississippi River to the west and bayous, cypress swamps, and oxbow lakes throughout.
This is as remote as Mississippi gets. There are no stoplights, no chain restaurants, no subdivisions. For buyers seeking ultra-cheap Delta farmland, wilderness-quality river land, or the kind of solitude that barely exists in the modern United States, Issaquena County is the end of the road — literally and figuratively.
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